I-MyOme yethule idatha evela kuphosta engqungqutheleni ye-American Society of Human Genetics (ASHG) ebigxile kumphumela ohlanganisiwe we-polygenic risk score (caIRS), ohlanganisa ufuzo nezici ezingokwesiko eziyingozi zomtholampilo ukuze kuthuthukiswe ukuhlonzwa kwabantu abasengcupheni enkulu ye-coronary artery disease. (CAD) kubantu abahlukahlukene.
Imiphumela yabonisa ukuthi i-caIRS ihlonze ngokunembe kakhudlwana abantu abasengcupheni ephakeme yokuba nesifo se-coronary artery, ikakhulukazi phakathi kwezigaba zengozi yomtholampilo emngceleni noma emaphakathi kanye nakubantu baseNingizimu Asia.
Ngokwesiko, amathuluzi amaningi okuhlola ubungozi be-CAD nokuhlolwa kuye kwaqinisekiswa kubantu abambalwa uma kuqhathaniswa, ngokusho kuka-Akash Kumar, MD, PhD, isikhulu sezokwelapha nesayensi se-MyOme.Ithuluzi elisetshenziswa kakhulu, i-Atherosclerotic Cardiovascular Disease (ASCVD) Pooled Cohort Equation (PCE), lithembele ezinyathelweni ezijwayelekile ezifana namazinga e-cholesterol nesimo sesifo sikashukela ukubikezela ingozi ye-CAD yeminyaka eyi-10 kanye nezinqumo eziqondisayo mayelana nokuqalwa kokwelashwa ngama-statin, kuphawula uKumar. .
Ihlanganisa izigidi zezinhlobonhlobo zofuzo
I-Polygenic risk scores (PRS), ehlanganisa izigidi zezinhlobonhlobo zofuzo zosayizi omncane womphumela zibe amaphuzu owodwa, zinikeza amandla okuthuthukisa ukunemba kwamathuluzi okuhlola ubungozi basemtholampilo,” kuqhuba u-Kumar.I-MyOme ithuthukise futhi yaqinisekisa amaphuzu engcuphe ahlanganisiwe ahlanganisa i-PRS yokhokho kanye ne-caIRS.
Okutholakele okubalulekile okuvela kuphrezentheshini kubonise ukuthi i-caIRS ithuthukise kakhulu ukucwaswa uma kuqhathaniswa ne-PCE kuwo wonke ama-cohorts okuqinisekisa kanye nokhokho abahloliwe.I-caIRS iphinde yahlonza amacala e-CAD engeziwe afinyelela kwangu-27 kubantu abayi-1,000 eqenjini le-PCE elisemngceleni/elimaphakathi.Ngaphezu kwalokho, abantu baseNingizimu Asia babonise ukwanda okukhulu kokucwaswa.
“Inani elihlanganisiwe lengozi le-MyOme lingase lithuthukise ukuvinjelwa nokuphathwa kwezifo ngaphakathi kokunakekelwa okuyisisekelo ngokuhlonza abantu abasengcupheni ephakeme yokuba ne-CAD, okungenzeka ukuthi bagejiwe,” kusho uKumar."Ngokuphawulekayo, i-caIRS iphumelele kakhulu ekuhlonzeni abantu baseNingizimu Asia abasengozini ye-CAD, okubalulekile ngenxa yezinga lokufa kwabo elicishe liphindwe kabili uma kuqhathaniswa nabaseYurophu."
Isethulo sephosta ye-Myome yayinesihloko esithi “Ukudidiyelwa Kwezibalo Zengozi Ye-Polygenic Nezici Zomtholampilo Kuthuthukisa I-10-year Risk Prediction of Coronary Artery Disease.”
Isikhathi sokuthumela: Nov-10-2023