Abahlaziyi bezinto zokukhula ezisuselwa ku-Platelet SEB-C100
Isingeniso somkhiqizo
I-Platelet Derived Growth Factor Analyzer iyithuluzi lokuhlola nokuhlaziya elisekelwe endleleni yokuhlola eyingqayizivele eqalwe inkampani yethu.I-analyzer ithola isici sokukhula esisuselwa ku-platelet, iphrotheni ethile umaka emchameni womuntu okhiqizwa lapho kwenzeka i-coronary artery stenosis.Ukuhlaziywa kungaqedwa emizuzwini embalwa ngokusebenzisa i-1ml yomchamo kuphela.Umhlaziyi anganquma ukuthi imithambo yenhliziyo inaso yini i-stenosis kanye nezinga le-stenosis ukuze anikeze ireferensi yokuhlolwa okwengeziwe.Indlela yokuthola nokuhlaziya ye-platelet-derived growth factor analyzer iyindlela yokuqala yokuthola engahlanyisi, engadingi imijovo nezidakamizwa ezisizayo, eqeda inkinga yokuthi abantu abangazwani nama-agent aqukethe i-iodine abakwazi ukwenza i-CT nezinye izifo zenhliziyo. i-angiography ye-artery.I-analyzer inezinzuzo zezindleko eziphansi zokuhlola, uhlelo olubanzi olubanzi, isicelo esilula, isivinini sokuhlola okusheshayo, njll., futhi iwuhlobo olusha lwe-coronary artery stenosis ukuthola kusenesikhathi kanye nethuluzi lokuhlola.
I-analyzer inezinzuzo ezilandelayo:
1. Ukushesha: Faka umchamo emshinini wokubona bese ulinda imizuzu embalwa
2. Usizo: Ukuhlolwa akutholakali ezibhedlela kuphela.Zingenziwa nasezikhungweni zokuhlolwa kwezempilo, emakhaya asebekhulile noma ezindlini zenhlalakahle yomphakathi
3. Ukunethezeka: Kudingeka i-1ml yomchamo kuphela njengesampula, alikhiphi igazi, alikhiphi mithi, akukho imijovo ehlukile, akukho kukhathazeka mayelana nokungezwani komzimba.
4. Intelligence: Ukuhlola okuzenzakalelayo ngokugcwele, ukusebenza kungagadiwe
5. Ukufakwa kalula: Usayizi omncane, ungafakwa futhi usetshenziswe nengxenye yetafula
6. Ukunakekela okulula: Igada ngokuzenzakalelayo futhi ibonise isimo esisebenzisekayo ukuze kube lula ukushintshwa
Isimiso somkhiqizo
I-Raman spectroscopy isebenzisa ukusabalalisa ukukhanya ukuze ihlaziye ngokushesha ukwakheka kwamangqamuzana.Le nqubo isekelwe esimisweni sokuthi lapho ukukhanya kukhipha i-molecule, ukungqubuzana okunwebekayo kwenzeka futhi ingxenye yokukhanya iyahlakazeka.Imvamisa yokukhanya okuhlakaziwe ihlukile emvamisa yokukhanya kwesigameko, okwaziwa ngele-Raman scattering.Ukuqina kokuhlakazeka kwe-Raman kuhlotshaniswa nesakhiwo se-molecule, okuvumela ukuhlaziya kokubili ukuqina kwayo kanye nemvamisa ukuze kutholwe ubunjalo be-molecule nokwakheka kwayo ngokunembile.
Ngenxa yesignali ye-Raman ebuthakathaka kanye nokuphazamiseka kwe-fluorescence okuvamile, ukuthola i-Raman spectra ngesikhathi sokutholwa kwangempela kungaba inselele.Ukutholwa okusebenzayo kwesiginali ye-Raman kunzima ngempela.Ngakho-ke, i-Raman spectroscopy ethuthukisiwe ingathuthukisa ngokuphawulekayo ukushuba kokukhanya okuhlakazekile kwe-Raman, kubhekwane nalezi zinkinga.Umgomo oyinhloko wale nqubo uhlanganisa ukubeka into ezotholwa endaweni ekhethekile yensimbi, njengesiliva noma igolide.ukuze udale indawo emaholoholo, eneleveli ye-nanometer, okuholela kumphumela wokuthuthukisa indawo.
Kwaboniswa ukuthi i-spectrum ye-Raman ye-marker platelet-derived growth factor (PDGF-BB) ibonise ukuphakama okuhlukile ku-1509 cm-1.Ngaphezu kwalokho, kwatholakala ukuthi ukuba khona kwe-marker platelet-derived growth factor (PDGF-BB) emchameni ehlobene ne-coronary artery stenosis.
Ngokusebenzisa i-Raman spectroscopy kanye nobuchwepheshe bokuthuthukisa indawo, isihlaziyi se-PDGF singakala ubukhona be-PDGF-BB kanye neziqongo zayo ezivelele emchameni.Lokhu kuvumela ukunqunywa kokuthi imithambo yenhliziyo iyi-stenotic kanye nezinga le-stenosis, ngaleyo ndlela inikeze isisekelo sokuxilongwa emtholampilo.
Ingemuva lomkhiqizo
Eminyakeni yamuva nje, ukwanda kwesifo senhliziyo kuye kwanda kancane kancane ngenxa yoshintsho lwemikhuba yokudla kanye nendlela yokuphila, kanye nokuguga kwabantu.Izinga lokufa elihlobene nesifo senhliziyo lisalokhu liphezulu ngendlela eshaqisayo.Ngokombiko we-China Cardiovascular Health and Disease Report 2022, izinga lokushona kwabantu besifo senhliziyo phakathi kwezakhamuzi zasemadolobheni aseShayina lizoba ngu-126.91/100,000 kanye no-135.88/100,000 phakathi kwezakhamuzi zasemakhaya ngo-2020. Lesi sibalo besilokhu sikhuphuka kusukela ngo-2012 nokwanda okukhulu ezindaweni zasemakhaya.Ku-2016, idlule izinga ledolobha futhi yaqhubeka ikhuphuka ngo-2020. Njengamanje, i-coronary arteriography iyindlela eyinhloko yokuxilonga esetshenziselwa izilungiselelo zomtholampilo ukuze kutholakale isifo senhliziyo.Nakuba ibizwa ngokuthi "izinga legolide" lokuxilongwa kwesifo senhliziyo, ukuhlasela kwayo kanye nezindleko eziphakeme kuye kwaholela ekwakhiweni kwe-electrocardiography njengendlela yokuhlola ethuthuka kancane kancane.Nakuba ukuxilongwa kwe-electrocardiogram (ECG) kulula, kulula, futhi kungabizi, ukuxilonga okungalungile kanye nokweqiwa kokuxilonga kusengenzeka, kukwenze kungathembeki ekuxilongeni komtholampilo kwesifo senhliziyo.Ngakho-ke, ukuthuthukiswa kwendlela engahlaseli, ebucayi kakhulu, futhi enokwethenjelwa yokutholwa ngokushesha kwesifo senhliziyo kubaluleke kakhulu.
I-Raman spectroscopy (i-SERS) ethuthukisiwe ebusweni ithole ukusetshenziswa okusabalele kusayensi yempilo yokuthola ama-biomolecules ezindaweni eziphansi kakhulu.Ngokwesibonelo, u-Alula et al.bakwazile ukuthola amaleveli amaminithi e-creatinine emchamweni ngokusebenzisa i-SERS spectroscopy enesithombe se-nanoparticles esiliva eshintshwe ngendlela ephawulekayo equkethe izinto kazibuthe.
Ngokufanayo, uMa et al.kusetshenziswe ukuhlanganisa okukhangwa kazibuthe kwama-nanoparticles ku-spectroscopy ye-SERS ukuze kwembule ukugxila okuphansi kakhulu kwe-deoxyribonucleic acid (DNA) kubhaktheriya.
I-Platelet-derived growth factor-BB (PDGF-BB) idlala indima ebalulekile ekuthuthukisweni kwe-atherosclerosis ngokusebenzisa izindlela eziningi futhi inobudlelwane obuseduze nesifo senhliziyo.I-Enzyme-linked immunosorbent assay (ELISA) iyindlela eyinhloko esetshenziswa ocwaningweni lwamanje lwe-PDGF-BB ukuthola le phrotheni egazini.Isibonelo, u-Yuran Zeng kanye nozakwabo banqume ukugcwala kwe-plasma ye-PDGF-BB ngokusebenzisa i-enzyme-linked immunosorbent assay futhi babona ukuthi i-PDGF-BB inegalelo elikhulu ku-pathogenesis ye-carotid atherosclerosis.Ocwaningweni lwethu, siqale sahlaziya i-SERS spectra yezixazululo ezahlukahlukene zamanzi ze-PDGF-BB ezinokugxila okuphansi kakhulu, sisebenzisa inkundla yethu ye-spectroscopy engu-785 nm Raman.Sithole ukuthi iziqongo zesici ezinokushintshwa kwe-Raman okungu-1509 cm-1 zabelwe isixazululo esimanzi se-PDGF-BB.Ukwengeza, sithole ukuthi lezi ziqongo zesici nazo zazihlotshaniswa nesixazululo esimanzi se-PDGF-BB.
Inkampani yethu ibambisene namathimba abacwaningi basenyuvesi ukwenza ukuhlaziya kwe-SERS spectroscopy enanini lamasampula omchamo angama-78.Lokhu kuhlanganisa amasampula angu-20 ezigulini ezihlinzwe nge-PCI, amasampula angu-40 ezigulini ezingazange zihlinzwe nge-PCI, kanye namasampula angu-18 avela kubantu abanempilo.Sihlaziye ngokucophelela i-spectra ye-SERS yomchamo ngokuhlanganisa iziqongo ze-Raman ne-Raman frequency shift engu-1509cm-1, exhunywe ngokuqondile ne-PDGF-BB.Ucwaningo lwembula ukuthi amasampula omchamo weziguli ezahlinzwa nge-PCI ayenophawu oluphawulekayo lwe-1509cm-1, kuyilapho lesi siqongo sasingekho kumasampula omchamo wabantu abanempilo kanye neziguli eziningi ezingezona ze-PCI.Ngesikhathi esifanayo, lapho idatha yomtholampilo yesibhedlela ye-coronary angiography ihlanganiswa, kwanqunywa ukuthi le ndlela yokuthola ihambisana kahle nokunquma ukuthi kukhona yini ukuvinjelwa kwenhliziyo nemithambo yegazi okudlula ama-70%.Ngaphezu kwalokho, le ndlela ingakwazi ukuxilonga ngokuzwela kanye nokucacile okungama-85% no-87% ngokulandelana, izinga lokuvinjelwa elingaphezu kuka-70% ezimeni ze-coronary artery disease ngokuhlonza izici eziphakeme ze-Raman ze-1509 cm-1.Ngakho-ke, i-5%, le ndlela kulindeleke ukuthi ibe yisisekelo esibalulekile sokunquma ukuthi iziguli ezinesifo se-coronary artery zidinga i-PCI, enikeza ukuqonda okuzuzisa kakhulu ukuze kutholwe amacala asolwayo e-coronary artery disease.
Uma kubhekwa lesi sizinda, inkampani yethu isebenzise imiphumela yocwaningo lwethu lwangaphambili ngokwethula iPlatelet Derived Growth Factor Analyzer.Lo mshini uzoshintsha kakhulu ukukhuthazwa nokusetshenziswa kabanzi kokutholwa kwesifo senhliziyo senhliziyo.Kuzoba negalelo elikhulu ekuthuthukiseni impilo yenhliziyo e-China nasemhlabeni jikelele.
I-Bibliography
[1] Huinan Yang, Chengxing Shen, Xiaoshu Cai et al.Ukuxilongwa okungavamisile futhi okulindelwe kwesifo senhliziyo ngomchamo kusetshenziswa i-Raman spectroscopy ethuthukisiwe phezulu [J].Umhlaziyi, 2018, 143, 2235–2242.
Amashidi wepharamitha
| inombolo yemodeli | SEB-C100 |
| into yokuhlola | Amandla okukhula kwe-platelet-derived growth factor iqophamlando emchameni |
| Izindlela Zokuhlola | okuzenzakalelayo |
| Ulimi | IsiShayina |
| Isimiso Sokuthola | I-Raman spectroscopy |
| isikhombikubona sokuxhumana | Imbobo ye-Micro USB, Imbobo Yenethiwekhi, i-WiFi |
| okuphindaphindwayo | I-coefficient yokuhluka kwemiphumela yokuhlolwa ≤ 1.0% |
| izinga lokunemba | Imiphumela ihambisana eduze namavelu esampula wamazinga ahambisanayo. |
| ukuzinza | I-coefficient of variation ≤1.0% yesampula efanayo phakathi namahora angu-8 okukhanyisa |
| Indlela yokurekhoda | Isibonisi se-LCD, isitoreji sedatha ye-FlashROM |
| isikhathi sokubona | Isikhathi sokutholwa sesampula eyodwa singaphansi kwamasekhondi angu-120 |
| Amandla Okusebenza | i-adaptha yamandla: AC 100V ~ 240V, 50/60Hz |
| izilinganiso zangaphandle | 700mm(L)*560mm(W)*400mm(H) |
| isisindo | Cishe ama-75kg |
| indawo yokusebenza | izinga lokushisa lokusebenza: 10℃～30℃;umswakama ohlobene: ≤90%;umfutho womoyaAmandla: 86kPa～106kPa |
| Indawo yokuthutha neyokugcina | izinga lokushisa lokusebenza: -40℃～55℃;umswakama ohlobene: ≤95%;umfutho womoyaAmandla: 86kPa～106kPa |
